ARG46021
anti-ATAD3A + ATAD3B antibody
anti-ATAD3A + ATAD3B antibody for Western blot,ICC/IF and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ATAD3A + ATAD3B |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ATAD3A + ATAD3B |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within aa. 110 - 160 of human ATAD3A + ATAD3B. |
| Conjugation | Un-conjugated |
| Alternate Names | ATAD3A; ATPase family AAA domain-containing protein 3A |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ATAD3A |
| Gene Full Name | ATPase family, AAA domain containing 3A |
| Background | ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008] |
| Function | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. [UniProt] |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20349121, PubMed:20154147). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578). [UniProt] |
| Calculated MW | 71 kDa |
Images (2) Click the Picture to Zoom In
-
ARG46021 anti-ATAD3A + ATAD3B antibody ICC/IF image
Immunofluorescence: Daudi stained with ARG46021 anti-ATAD3A + ATAD3B antibody.
-
ARG46021 anti-ATAD3A + ATAD3B antibody WB image
Western blot: Daudi stained with ARG46021 anti-ATAD3A + ATAD3B antibody.
