ARG46023
anti-ATG2B antibody
anti-ATG2B antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ATG2B |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ATG2B |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within aa. 450 - 500 of human ATG2B. |
| Conjugation | Un-conjugated |
| Alternate Names | ATG2B; C14orf103; C14orf103; Autophagy-related protein 2 homolog B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -73°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96BY7 Human Autophagy-related protein 2 homolog B |
|---|---|
| Gene Symbol | ATG2B |
| Gene Full Name | autophagy-related protein 2 homolog B |
| Background | This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016] |
| Function | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). [UniProt] |
| Cellular Localization | Endoplasmic reticulum; Lipid droplet; Membrane. [UniProt] |
| Calculated MW | 233 kDa |
| PTM | Phosphoprotein. [UniProt] |
