anti-Aquaporin 4 antibody

anti-Aquaporin 4 antibody for ICC/IF,Immunohistochemistry,Western blot and Human,Mouse,Rat

publication_link Publication2


Product Description

Rabbit Polyclonal antibody recognizes Aquaporin 4

Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, IHC, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Aquaporin 4
Antigen Species Rat
Immunogen Synthetic peptide around the C-terminus of Rat Aquaporin 4. (N-CTKGSYMEVEDNRSQVETED)
Conjugation Un-conjugated
Alternate Names HMIWC2; Aquaporin-4; Mercurial-insensitive water channel; AQP-4; MIWC; WCH4

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Purification with Protein A.
Buffer PBS, 0.09% Sodium azide and 50% Glycerol
Preservative 0.09% Sodium azide
Stabilizer 50% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 11829 Mouse AQP4

GeneID: 25293 Rat AQP4

GeneID: 361 Human AQP4

Gene Symbol Aqp4
Gene Full Name aquaporin 4
Background This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. [UniProt]
Cellular Localization Membrane
Calculated MW 35 kDa (unmodified); 50 kDa (glycosylated)
PTM Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40% (By similarity).

Images (2) Click the Picture to Zoom In

  • ARG22361 anti-Aquaporin 4 antibody IHC image

    Immunohistochemistry: Rat kidney tissue stained with ARG22361 anti-Aquaporin 4 antibody (green) at 1:200 dilution.

  • ARG22361 anti-Aquaporin 4 antibody WB image

    Western blot: Rat kidney inner medullary homogenates stained with ARG22361 anti-Aquaporin 4 antibody at 1:2000 dilution.

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Sample:MCF7 and U87

Sample Loading Amount:20 µg

Primary Antibody Dilution Factor:1:1500

Primary Antibody Incubation Time:overnight

Primary Antibody Incubation Temperature:4 ºC

Specific References

AQP4 Attenuated TRAF6/NFκB Activation in Acrylamide-Induced Neurotoxicity

WB / Rat

Chia-Yu Hung et al.
Molecules,  (2022)




Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.

WB, ICC/IF / Rat

Gao Xuan et al.
Life Sci.,  (2019)