ARG67258
anti-BCOR / BCL6 corepressor antibody [SQab30374]
anti-BCOR / BCL6 corepressor antibody [SQab30374] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30374] recognizes BCOR / BCL6 corepressor. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30374 |
| Isotype | IgG |
| Target Name | BCOR / BCL6 corepressor |
| Immunogen | Recombinant protein |
| Conjugation | Un-conjugated |
| Alternate Names | BCOR; BCL6 Corepressor; KIAA1575; BCL6 Interacting Corepressor; BCL-6 Corepressor; BCL-6 Coreceptor; FLJ20285; BCL-6 Interacting Corepressor; BCL6 Co-Repressor; MCOPS2; ANOP2; MAA2; BCoR |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BCOR |
| Gene Full Name | BCL6 Corepressor |
| Background | The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010] |
| Function | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| Calculated MW | 192 kDa |
| PTM | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG67258 anti-BCOR / BCL6 corepressor antibody [SQab30374] IHC-P image
Immunohistochemistry: Human Endometrial Cancer stained with ARG67258 anti-BCOR / BCL6 corepressor antibody [SQab30374] at 1:100 dilution.
