ARG54829

anti-BMPR1A antibody

anti-BMPR1A antibody for Western blot,Flow cytometry and Human

Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes BMPR1A
Tested Reactivity Hu
Tested Application FACS, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name BMPR1A
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 1-30 (N-terminus) of Human BMPR1A.
Conjugation Un-conjugated
Alternate Names CD292; CD antigen CD292; ALK3; ACVRLK3; ALK-3; EC 2.7.11.30; Activin receptor-like kinase 3; 10q23del; Serine/threonine-protein kinase receptor R5; BMPR-1A; BMP type-1A receptor; SKR5; Bone morphogenetic protein receptor type-1A

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:10 - 1:50
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human liver

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 657 Human BMPR1A

Swiss-port # P36894 Human Bone morphogenetic protein receptor type-1A

Gene Symbol BMPR1A
Gene Full Name bone morphogenetic protein receptor, type IA
Background The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity). [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein
Research Area Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody
Calculated MW 60 kDa

Images (2) Click the Picture to Zoom In

  • ARG54829 anti-BMPR1A antibody WB image

    Western blot: 35 µg of Human liver lysate stained with ARG54829 anti-BMPR1A antibody at 1:1000 dilution.

  • ARG54829 anti-BMPR1A antibody FACS image

    Flow Cytometry: WiDr cells stained with ARG54829 anti-BMPR1A antibody (bottom histogram) or without primary antibody control (top histogram), followed by incubation with FITC labelled secondary antibody.