ARG54831

anti-BMPR1B antibody

anti-BMPR1B antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human

Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes BMPR1B
Tested Reactivity Hu
Predict Reactivity Ms, Chk
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name BMPR1B
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 472-502 (C-terminus) of Human BMPR1B.
Conjugation Un-conjugated
Alternate Names ALK6; CDw293; EC 2.7.11.30; ALK-6; BMP type-1B receptor; BMPR-1B; Bone morphogenetic protein receptor type-1B; CD antigen CDw293

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-PAssay-dependent
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control NCI-H460

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 658 Human BMPR1B

Swiss-port # O00238 Human Bone morphogenetic protein receptor type-1B

Gene Symbol BMPR1B
Gene Full Name bone morphogenetic protein receptor, type IB
Background This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity). [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein
Research Area Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody
Calculated MW 57 kDa

Images (2) Click the Picture to Zoom In

  • ARG54831 anti-BMPR1B antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human cancer tissue stained with ARG54831 anti-BMPR1B antibody.

  • ARG54831 anti-BMPR1B antibody WB image

    Western blot: NCI-H460 cell lysate stained with ARG54831 anti-BMPR1B antibody.