ARG46048
anti-BOK antibody
anti-BOK antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BOK |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BOK |
| Antigen Species | Human |
| Immunogen | A 16 amino acid synthetic peptide within the first 50 amino acids of human BOK. |
| Conjugation | Un-conjugated |
| Alternate Names | BOK; Bcl-2-related ovarian killer protein; Bcl-2-like protein 9; BCL2L9; hBOK; BOKL; Bcl2-L-9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UMX3 Human Bcl-2-related ovarian killer protein |
|---|---|
| Gene Symbol | BOK |
| Gene Full Name | BCL2-related ovarian killer |
| Background | Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus. |
| Function | Induces apoptosis in a manner dependent on BAX and BAK. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG46048 anti-BOK antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG46048 anti-BOK antibody.
