ARG45563
anti-BRD1 / BRL antibody
anti-BRD1 / BRL antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BRD1 / BRL |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BRD1 / BRL |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human BRD1 / BRL. |
| Conjugation | Un-conjugated |
| Alternate Names | BRD1; Bromodomain Containing 1; BRPF2; BRL; Bromodomain And PHD Finger-Containing Protein 2; Bromodomain-Containing Protein 1; BR140-Like Protein; Bromodomain-Containing 1; BR140-Like; BRPF1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 120 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | BRD1 |
|---|---|
| Gene Full Name | Bromodomain Containing 1 |
| Background | This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017] |
| Function | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation. [UniProt] |
| Cellular Localization | Chromosome; Nucleus. [UniProt] |
| Calculated MW | 120 kDa |
| PTM | Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45563 anti-BRD1 / BRL antibody ICC/IF image
Immunofluorescence: Hela stained with ARG45563 anti-BRD1 / BRL antibody at 5 μg/ml dilution.
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ARG45563 anti-BRD1 / BRL antibody WB image
Western blot: 293T stained with ARG45563 anti-BRD1 / BRL antibody at 0.5 μg/ml dilution.
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ARG45563 anti-BRD1 / BRL antibody WB image
Western blot: Rat testis stained with ARG45563 anti-BRD1 / BRL antibody at 0.5 μg/ml dilution.
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ARG45563 anti-BRD1 / BRL antibody FACS image
Flow Cytometry: SH-SY5Y stained with ARG45563 anti-BRD1 / BRL antibody at 1 µg/10^6 cells dilution.
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ARG45563 anti-BRD1 / BRL antibody WB image
Western blot: Mouse thymus stained with ARG45563 anti-BRD1 / BRL antibody at 0.5 μg/ml dilution.
