ARG10553
anti-Bax antibody [T22-A] (FITC)
anti-Bax antibody [T22-A] (FITC) for Flow cytometry and Human
Overview
| Product Description | FITC-conjugated Rabbit Monoclonal antibody [T22-A] recognizes Bax |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | T22-A |
| Isotype | IgG |
| Target Name | Bax |
| Antigen Species | Human |
| Conjugation | FITC |
| Full Name | BCL2-associated X protein |
| Alternate Names | Bcl-2-like protein 4; Bcl2-L-4; BCL2L4; Apoptosis regulator BAX |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | Aqueous buffer solution, 0.05% Sodium azide and 10 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 10 mg/ml BSA |
| Storage instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database links | |
|---|---|
| Gene Symbol | BAX |
| Gene Full Name | BCL2-associated X protein |
| Background | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] |
| Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. [UniProt] |
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ARG10553 anti-Bax antibody [T22-A] (FITC) FACS image
Flow Cytometry: Hek293 cells were fixed, permeabilized and stained with ARG10553 anti-Bax antibody [T22-A] (FITC) (blue, 10 µl per test) or with an isotype control (black).
