ARG67313
anti-CACNA1C antibody
anti-CACNA1C antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CACNA1C |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CACNA1C |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide within the center region of Human CACNA1C. |
| Conjugation | Un-conjugated |
| Alternate Names | Calcium Voltage-Gated Channel Subunit Alpha1 C; CACNA1C; Cav1.2; CACH2; CACN2; CACNL1A1; CCHL1A1; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 190 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CACNA1C |
| Gene Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 C |
| Background | This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012] |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). [UniProt] |
| Cellular Localization | Cell membrane; Cell projection; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| Calculated MW | 249 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG67313 anti-CACNA1C antibody ICC/IF image
Immunofluorescence: MCF7 stained with ARG67313 anti-CACNA1C antibody.
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ARG67313 anti-CACNA1C antibody WB image
Western blot: Rat brain stained with ARG67313 anti-CACNA1C antibody.
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ARG67313 anti-CACNA1C antibody WB image
Western blot: Mouse brain stained with ARG67313 anti-CACNA1C antibody.
