ARG46059
anti-CAPS2 antibody
anti-CAPS2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CAPS2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CAPS2 |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within aa. 510 - 560 of human CAPS2. |
| Conjugation | Un-conjugated |
| Alternate Names | CADPS2; Ca++-dependent secretion activator 2; CAPS2; CAPS2; KIAA1591; Calcium-dependent secretion activator 2; Calcium-dependent activator protein for secretion 2; CAPS-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 150 kDa |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -109°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q86UW7 Human Calcium-dependent secretion activator 2 Swiss-port # Q8BYR5 Mouse Calcium-dependent secretion activator 2 |
|---|---|
| Gene Symbol | CADPS2 |
| Gene Full Name | Ca++-dependent secretion activator 2 |
| Background | This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). [UniProt] |
| Cellular Localization | Cell projection; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Membrane; Synapse. [UniProt] |
| Calculated MW | 138,145 kDa |
| PTM | Phosphoprotein. [UniProt] |
