anti-CD103 / Integrin alpha E antibody [2E7]

anti-CD103 / Integrin alpha E antibody [2E7] for Cellular activation ,Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Mouse


Product Description Hamster Monoclonal antibody [2E7] recognizes CD103 / Integrin alpha E
Tested Reactivity Ms
Tested Application Cell-Act , FACS, IHC-Fr, IP
Specificity Mouse CD103
Host Hamster
Clonality Monoclonal
Clone 2E7
Isotype IgG2
Target Name CD103 / Integrin alpha E
Antigen Species Mouse
Immunogen C57BL/6J Mouse intestinal intraepithelial lymphocytes (IEL)
Conjugation Un-conjugated
Alternate Names CD103; HUMINAE; Integrin alpha-E; Mucosal lymphocyte 1 antigen; CD antigen CD103; HML-1 antigen; Integrin alpha-IEL

Application Instructions

Application Suggestion
Tested Application Dilution
Cell-Act Assay-dependent
Application Note Cellular activation: This clone up-regulates CD5 surface expression on CD8 alpha/beta+ gut IEL cells (gut intraepithelial lymphocytes)
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 16407 Mouse ITGAE

Swiss-port # Q60677 Mouse Integrin alpha-E

Gene Symbol ITGAE
Gene Full Name integrin alpha E, epithelial-associated
Background Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Function Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. [UniProt]
Calculated MW 130 kDa