anti-CD106 / VCAM1 antibody [1.G11B1]
anti-CD106 / VCAM1 antibody [1.G11B1] for Blocking,ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Human,Pig
|Product Description||Mouse Monoclonal antibody [1.G11B1] recognizes CD106 / VCAM1|
|Tested Reactivity||Hu, Pig|
|Tested Application||BL, ELISA, FACS, ICC/IF, IHC-Fr, IP, WB|
|Specificity||Human/Porcine CD106. The clone 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium.|
|Target Name||CD106 / VCAM1|
|Full Name||vascular cell adhesion molecule 1|
|Alternate Names||CD106; INCAM-100; Vascular cell adhesion protein 1; VCAM-1; CD antigen CD106; V-CAM 1|
|Application Note||WB: Under non-reducing condition.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Calculated MW||81 kDa|
|Buffer||BBS (pH 8.2)|
|Storage instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||vascular cell adhesion molecule 1|
|Background||This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]|
|Function||Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt]|
Images (1) Click the Picture to Zoom In
ARG20962 anti-CD106 / VCAM1 antibody [1.G11B1] FACS image
Flow Cytometry: TNFα stimulated Human endothelial cell line HUV-EC-C was stained with ARG20962 anti-CD106 / VCAM1 antibody [1.G11B1] followed by ARG21884 Goat anti-Mouse IgG1 antibody (FITC) (pre-adsorbed).