anti-CD107a / LAMP1 antibody [H4A3] (PE)

anti-CD107a / LAMP1 antibody [H4A3] (PE) for Flow cytometry and Human,Mouse,Primates

Cancer antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody; Lysosome Marker antibody


Product Description PE-conjugated Mouse Monoclonal antibody [H4A3] recognizes CD107a / LAMP1
Tested Reactivity Hu, Ms, NHuPrm
Tested Application FACS
Specificity The mouse monoclonal antibody H4A3 recognizes LAMP1 / CD107a, an approximately 100120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
Host Mouse
Clonality Monoclonal
Clone H4A3
Isotype IgG1
Target Name CD107a / LAMP1
Antigen Species Human
Immunogen Human PBMC
Conjugation PE
Alternate Names LGP120; CD107a; LAMPA; CD antigen CD107a; Lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; LAMP-1; Lysosome-associated membrane protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS4 µl / 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Note The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Buffer PBS, 0.02% Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 0.02% Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 16783 Mouse LAMP1

GeneID: 3916 Human LAMP1

Swiss-port # P11279 Human Lysosome-associated membrane glycoprotein 1

Swiss-port # P11438 Mouse Lysosome-associated membrane glycoprotein 1

Gene Symbol LAMP1
Gene Full Name lysosomal-associated membrane protein 1
Background CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.
Function Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. [UniProt]
Research Area Cancer antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody; Lysosome Marker antibody
Calculated MW 45 kDa
PTM O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Images (1) Click the Picture to Zoom In

  • ARG54251 anti-CD107a / LAMP1 antibody [H4A3] (PE) FACS image

    Flow Cytometry: Human peripheral blood cells stained with ARG54251 anti-CD107a / LAMP1 antibody [H4A3] (PE).

Clone References

Cellular mechanisms of toll-like receptor-3 activation in the thalamus are associated with white matter injury in the developing brain.

Vontell R et al.
J Neuropathol Exp Neurol.,  (2015)




Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma.

Abu-Hassan DW et al.
Stem Cells.,  (2015)




QSOX1 inhibits autophagic flux in breast cancer cells.

ICC/IF / Human

Poillet L et al.
PLoS One.,  (2014)




Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.

ICC/IF / Rat

Noam Y et al.
J Biol Chem.,  (2014)




Blood-brain barrier impairment in MPS III patients.

IHC-Fr / Human

Garbuzova-Davis S et al.
BMC Neurol.,  (2013)




Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.

WB / Human

Manzoni C et al.
Biochem Biophys Res Commun.,  (2013)




Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model.

WB / Rhesus monkey

Deng S et al.
PLoS One.,  (2013)




Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.

ICC/IF / Mouse

Xia T et al.
ACS Nano.,  (2008)