anti-CD11c antibody [BU15] (APC)

anti-CD11c antibody [BU15] (APC) for Flow cytometry and Human,Monkey

Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody


Product Description

APC-conjugated Mouse Monoclonal antibody [BU15] recognizes CD11c

Tested Reactivity Hu, Mk
Tested Application FACS
Specificity The clone BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
HLDA III; WS Code M 256
HLDA V; WS Code AS S143
HLDA VI; WS Code AS Ref.6
Host Mouse
Clonality Monoclonal
Clone BU15
Isotype IgG1
Target Name CD11c
Immunogen Dendritic cells of synovial fluid
Conjugation APC
Alternate Names CD antigen CD11c; Leu M5; CD11C; SLEB6; Integrin alpha-X; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11 antigen-like family member C

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Note The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Buffer PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 15 mM Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 3687 Human ITGAX

Swiss-port # P20702 Human Integrin alpha-X

Gene Symbol ITGAX
Gene Full Name integrin, alpha X (complement component 3 receptor 4 subunit)
Background CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
Function Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [UniProt]
Research Area Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody
Calculated MW 128 kDa

Images (1) Click the Picture to Zoom In

  • ARG53761 anti-CD11c antibody [BU15] (APC) FACS image

    Flow Cytometry: Human peripheral blood cells stained with ARG53761 anti-CD11c antibody [BU15] (APC).

Clone References

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.

FACS / Human

Xue L et al.
J Allergy Clin Immunol.,  (2014)




A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

FACS / Human

Salimi M et al.
J Exp Med.,  (2013)




Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Rezzonico R et al.
Blood.,  (2001)