ARG21136

anti-CD21 antibody [BB6-11C9.6] (Biotin)

anti-CD21 antibody [BB6-11C9.6] (Biotin) for Flow cytometry,IHC-Frozen sections and Pig

Overview

Product Description Biotin-conjugated Mouse Monoclonal antibody [BB6-11C9.6] recognizes CD21
Tested Reactivity Pig
Tested Application FACS, IHC-Fr
Specificity Porcine CD21. The clone BB6-11C9.6 stains the following percentages of surface immunoglobulin (sIg) positive cells in porcine lymphoid tissues - 92-96% in peripheral blood, 74-98% in mesenteric lymph nodes, 97-100% in ileal Peyer’s patches (ILPP), 93-97% in spleen, and 0% in thymus. The antibody does not stain B cells in cord blood or spleen from pig fetuses (105 days gestation).
Host Mouse
Clonality Monoclonal
Clone BB6-11C9.6
Isotype IgG1, kappa
Target Name CD21
Species Pig
Conjugation Biotin
Full Name complement component (3d/Epstein Barr virus) receptor 2
Alternate Names Cr2; Complement C3d receptor; C3DR; CD21; CD antigen CD21; Complement receptor type 2; SLEB9; CR; CVID7; Epstein-Barr virus receptor; EBV receptor

Application Instructions

Application Suggestion
Tested Application Dilution
FACS< 1 µg/10^6 cells
IHC-FrAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 113 kDa

Properties

Form Liquid
Buffer PBS and Sodium azide
Preservative Sodium azide
Concentration 0.5 mg/ml
Storage instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol CR2
Gene Full Name complement component (3d/Epstein Barr virus) receptor 2
Background CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
Function Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG21136 anti-CD21 antibody [BB6-11C9.6] (Biotin) FACS image

    Flow Cytometry: Porcine peripheral blood lymphocytes stained with ARG21136 anti-CD21 antibody [BB6-11C9.6] (Biotin) and ARG21114 anti-CD3e antibody [PPT3] (PE).