anti-CD23 antibody [2G8] (APC)
anti-CD23 antibody [2G8] (APC) for Flow cytometry,IHC-Frozen sections and Mouse
|Product Description||APC-conjugated Rat Monoclonal antibody [2G8] recognizes CD23|
|Tested Application||FACS, IHC-Fr|
|Immunogen||FcεR isolated from B cell lymphoma cell line M12.4.5|
|Full Name||Fc receptor, IgE, low affinity II, alpha polypeptide|
|Alternate Names||CD23A; BLAST-2; Lymphocyte IgE receptor; CLEC4J; Immunoglobulin E-binding factor; CD23; IGEBF; Fc-epsilon-RII; CD antigen CD23; FCE2; Low affinity immunoglobulin epsilon Fc receptor; C-type lectin domain family 4 member J|
|Application Note||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|Buffer||PBS, 0.1% Sodium azide and Sucrose.|
|Preservative||0.1% Sodium azide|
|Storage instruction||Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Background||The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]|
|Function||Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). [UniProt]|
|Calculated MW||36 kDa|
|PTM||N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
Images (1) Click the Picture to Zoom In
ARG20877 anti-CD23 antibody [2G8] (APC) FACS image
Flow Cytometry: BALB/c Mouse splenocytes stained with ARG20877 anti-CD23 antibody [2G8] (APC) and ARG20817 anti-CD3e antibody [C363.29B] (FITC).