anti-CD261 / TRAIL R1 antibody [DR-4-02] (FITC)

anti-CD261 / TRAIL R1 antibody [DR-4-02] (FITC) for Flow cytometry and Human

Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody


Product Description FITC-conjugated Mouse Monoclonal antibody [DR-4-02] recognizes CD261 / TRAIL R1
Tested Reactivity Hu
Tested Application FACS
Specificity The clone DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Host Mouse
Clonality Monoclonal
Clone DR-4-02
Isotype IgG1
Target Name CD261 / TRAIL R1
Antigen Species Human
Immunogen Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Conjugation FITC
Alternate Names TNF-related apoptosis-inducing ligand receptor 1; CD antigen CD261; TRAILR-1; DR4; Tumor necrosis factor receptor superfamily member 10A; CD261; Death receptor 4; APO2; TRAIL receptor 1; TRAIL-R1; TRAILR1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS3 - 5 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Note The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Buffer PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 15 mM Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Concentration 0.1 mg/ml
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 8797 Human TNFRSF10A

Swiss-port # O00220 Human Tumor necrosis factor receptor superfamily member 10A

Gene Symbol TNFRSF10A
Gene Full Name tumor necrosis factor receptor superfamily, member 10a
Background TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.
Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Calculated MW 50 kDa

Images (1) Click the Picture to Zoom In

  • ARG53804 anti-CD261 / TRAIL R1 antibody [DR-4-02] (FITC) FACS image

    Flow Cytometry: CD261-transfected HEK293 cells stained with ARG53804 anti-CD261 / TRAIL R1 antibody [DR-4-02] (FITC).

Clone References

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells.

Passante E et al.
Cell Death Differ.,  (2013)




Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas.

FACS / Human

Nesterenko I et al.
PLoS One.,  (2012)




Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.

ICC/IF / Human

Vondálová Blanárová O et al.
Carcinogenesis.,  (2011)




Scatter factor protects tumor cells against apoptosis caused by TRAIL.

IP / 

Fan S et al.
Anticancer Drugs.,  (2010)




Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.

Franzen CA et al.
Mol Cancer Res.,  (2009)