anti-CD262 / TRAIL R2 antibody

anti-CD262 / TRAIL R2 antibody for Flow cytometry,ICC/IF,Western blot and Human


Product Description Rabbit Polyclonal antibody recognizes CD262 / TRAIL R2
Tested Reactivity Hu
Tested Application FACS, ICC/IF, WB
Specificity Human DR5
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD262 / TRAIL R2
Antigen Species Human
Immunogen Recombinant Human DR5 protein.
Conjugation Un-conjugated
Alternate Names TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9

Application Instructions

Application Suggestion
Tested Application Dilution
FACS< 3 ug/10^6 cells
WB< 2 ug/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 8795 Human TNFRSF10B

Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B

Gene Symbol TNFRSF10B
Gene Full Name tumor necrosis factor receptor superfamily, member 10b
Background The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt]
Calculated MW 48 kDa

Images (3) Click the Picture to Zoom In

  • ARG22343 anti-CD262 / TRAIL R2 antibody ICC/IF image

    Immunofluorescence: Human hepatocellular carcinoma cell line HepG2 stained with Rabbit IgG isotype control (left) and ARG22343 anti-CD262 / TRAIL R2 antibody (right) followed by ARG21782 Donkey anti-Rabbit IgG (H+L) antibody (Biotin) (pre-adsorbed), Streptavidin (Cy3) and DAPI.

  • ARG22343 anti-CD262 / TRAIL R2 antibody WB image

    Western blot: Jurkat cell lysate stained with ARG22343 anti-CD262 / TRAIL R2 antibody. Secondary antibody: ARG23768 Goat anti-Rabbit IgG (H+L) antibody (HRP) (pre-adsorbed).

  • ARG22343 anti-CD262 / TRAIL R2 antibody FACS image

    Flow Cytometry: Human T cell leukemia cell line Jurkat was stained with ARG22343 anti-CD262 / TRAIL R2 antibody followed by ARG23752 Mouse anti-Rabbit IgG antibody [2A9] (PE).