ARG10557

anti-CD34 antibody [Q19-E]

anti-CD34 antibody [Q19-E] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [Q19-E] recognizes CD34
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone Q19-E
Isotype IgG
Target Name CD34
Antigen Species Human
Immunogen Synthetic peptide around the N-terminus of Human CD34
Conjugation Un-conjugated
Full Name CD34 molecule
Alternate Names Hematopoietic progenitor cell antigen CD34; CD antigen CD34

Application Instructions

Application Suggestion
Tested Application
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 947 Human CD34

Swiss-port # P28906 Human Hematopoietic progenitor cell antigen CD34

Gene Symbol CD34
Gene Full Name CD34 molecule
Background The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. [UniProt]
PTM Highly glycosylated.
Phosphorylated on serine residues by PKC.

(2) Click the Picture to Zoom In

  • ARG10557 anti-CD34 antibody [Q19-E] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded Human GIST (gastrointestinal stromal tumor) of small intestine (4 µm sections) stained with ARG10557 anti-CD34 antibody [Q19-E].

  • ARG10557 anti-CD34 antibody [Q19-E] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded Human endothelium of the muscular artery (4 µm sections) stained with ARG10557 anti-CD34 antibody [Q19-E].