anti-CD358 / DR6 antibody

anti-CD358 / DR6 antibody for Western blot and Human

Cell Biology and Cellular Response antibody; Cell Death antibody


Product Description Rabbit Polyclonal antibody recognizes CD358 / DR6
Tested Reactivity Hu
Tested Application WB
Specificity This antibody recognizes human DR6 (68kDa).
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD358 / DR6
Antigen Species Human
Immunogen Peptide corresponding to aa 42-56 of human DR6 precursor (accession no. AF068868).
Conjugation Un-conjugated
Alternate Names CD antigen CD358; CD358; Tumor necrosis factor receptor superfamily member 21; DR6; Death receptor 6; BM-018

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control K562 and Raji


Form Liquid
Purification Immunoaffinity chroma-tography
Buffer PBS (pH 7.4) and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 27242 Human TNFRSF21

Swiss-port # O75509 Human Tumor necrosis factor receptor superfamily member 21

Gene Symbol TNFRSF21
Gene Full Name tumor necrosis factor receptor superfamily, member 21
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain-containing receptor in the TNF receptor family was recently described and designated DR6. Like TNF-R1, DR6 interacts with death domain-containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF- B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 is under investigation.
Function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Cell Death antibody
Calculated MW 72 kDa

Images (1) Click the Picture to Zoom In

  • ARG54358 anti-CD358 / DR6 antibody WB image

    Western blot: K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide stained with ARG54358 anti-CD358 / DR6 antibody at 2 μg/ml dilution.