anti-CD40 antibody [1C10]

anti-CD40 antibody [1C10] for Blocking,Cellular activation ,Flow cytometry,Immunoprecipitation and Mouse

Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Pro-B Cell Marker antibody; Pre-B Cell Marker antibody


Product Description Rat Monoclonal antibody [1C10] recognizes CD40
Tested Reactivity Ms
Tested Application BL, Cell-Act , FACS, IP
Specificity Mouse CD40.
Host Rat
Clonality Monoclonal
Clone 1C10
Isotype IgG2a, kappa
Target Name CD40
Antigen Species Mouse
Immunogen sCD40
Conjugation Un-conjugated
Alternate Names CDw40; CD antigen CD40; Tumor necrosis factor receptor superfamily member 5; Bp50; CD40L receptor; CDW40; TNFRSF5; p50; B-cell surface antigen CD40

Application Instructions

Application Suggestion
Tested Application Dilution
Cell-Act Assay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 21939 Mouse CD40

Swiss-port # P27512 Mouse Tumor necrosis factor receptor superfamily member 5

Gene Symbol CD40
Gene Full Name CD40 antigen
Background This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Pro-B Cell Marker antibody; Pre-B Cell Marker antibody
Calculated MW 31 kDa

Images (1) Click the Picture to Zoom In

  • ARG20924 anti-CD40 antibody [1C10] FACS image

    Flow Cytometry: BALB/c Mouse splenocytes stained with ARG20924 anti-CD40 antibody [1C10] followed by ARG21700 Mouse anti-Rat IgG2a antibody [2A8F4] (FITC).