ARG10558

anti-CD45 antibody [E19-G]

anti-CD45 antibody [E19-G] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [E19-G] recognizes CD45
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone E19-G
Isotype IgG
Target Name CD45
Antigen Species Human
Immunogen Synthetic peptide around the C-terminus of Human CD45
Conjugation Un-conjugated
Full Name protein tyrosine phosphatase, receptor type, C
Alternate Names LY5; GP180; Receptor-type tyrosine-protein phosphatase C; CD45; L-CA; CD antigen CD45; Leukocyte common antigen; CD45R; LCA; T200; EC 3.1.3.48; B220

Application Instructions

Application Suggestion
Tested Application
IHC-P1:100 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 5788 Human PTPRC

Swiss-port # P08575 Human Receptor-type tyrosine-protein phosphatase C

Gene Symbol PTPRC
Gene Full Name protein tyrosine phosphatase, receptor type, C
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). [UniProt]
Highlight Related products:
CD45 antibodies; CD45 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
Related news:
Lymphoma
PTM Heavily N- and O-glycosylated.

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  • ARG10558 anti-CD45 antibody [E19-G] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded Human lymphoid cells of the palatine tonsil (4 µm sections) stained with ARG10558 anti-CD45 antibody [E19-G].

  • ARG10558 anti-CD45 antibody [E19-G] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded Human lymph node (4 µm sections) stained with ARG10558 anti-CD45 antibody [E19-G].