ARG21285

anti-CD49b / Integrin alpha 2 antibody [HAS-4] (FITC)

anti-CD49b / Integrin alpha 2 antibody [HAS-4] (FITC) for Blocking,Flow cytometry,ICC/IF,IHC-Frozen sections and Human

Overview

Product Description FITC-conjugated Mouse Monoclonal antibody [HAS-4] recognizes CD49b / Integrin alpha 2
Tested Reactivity Hu
Tested Application BL, FACS, ICC/IF, IHC-Fr
Specificity Human CD49b.
Host Mouse
Clonality Monoclonal
Clone HAS-4
Isotype IgG2a, kappa
Target Name CD49b / Integrin alpha 2
Antigen Species Human
Immunogen Human keratinocytes
Conjugation FITC
Full Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Alternate Names Collagen receptor; VLA-2 subunit alpha; HPA-5; CD49B; CD49 antigen-like family member B; GPIa; VLA-2; CD antigen CD49b; BR; VLAA2; Platelet membrane glycoprotein Ia; Integrin alpha-2

Application Instructions

Application Suggestion
Tested Application Dilution
BLAssay-dependent
FACS10 µl/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 129 kDa

Properties

Form Liquid
Buffer PBS and Sodium azide
Preservative Sodium azide
Storage instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3673 Human ITGA2

Swiss-port # P17301 Human Integrin alpha-2

Gene Symbol ITGA2
Gene Full Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Background This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG21285 anti-CD49b / Integrin alpha 2 antibody [HAS-4] (FITC) FACS image

    Flow Cytometry: Human peripheral blood platelets stained with ARG21285 anti-CD49b / Integrin alpha 2 antibody [HAS-4] (FITC).