anti-CD49e / Integrin alpha 5 antibody [5H10.27]

anti-CD49e / Integrin alpha 5 antibody [5H10.27] for Flow cytometry,IHC-Frozen sections,Blocking and Mouse


Product Description Rat Monoclonal antibody [5H10.27] recognizes CD49e / Integrin alpha 5
Tested Reactivity Ms
Tested Application BL, FACS, IHC-Fr
Specificity Mouse CD49e
Host Rat
Clonality Monoclonal
Clone 5H10.27
Isotype IgG2a, kappa
Target Name CD49e / Integrin alpha 5
Antigen Species Mouse
Immunogen C57BL/6 x A/J F1 Mouse mast cell line MC/9
Conjugation Un-conjugated
Alternate Names CD49e; CD49 antigen-like family member E; Integrin alpha-F; Fibronectin receptor subunit alpha; CD antigen CD49e; VLA-5; FNRA; VLA5A; Integrin alpha-5

Application Instructions

Application Suggestion
Tested Application Dilution
FACS< 1 µg/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 16402 Mouse ITGA5

Swiss-port # P11688 Mouse Integrin alpha-5

Gene Symbol ITGA5
Gene Full Name integrin alpha 5 (fibronectin receptor alpha)
Background The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]
Highlight Related products:
CD49e antibodies; Anti-Rat IgG secondary antibodies;
Calculated MW 115 kDa
PTM Proteolytic cleavage by PCSK5 mediates activation of the precursor.