anti-CD49e / Integrin alpha 5 antibody [SNAKA51]

anti-CD49e / Integrin alpha 5 antibody [SNAKA51] for Functional study,ICC/IF,Western blot and Human


Product Description Mouse Monoclonal antibody [SNAKA51] recognizes CD49e / Integrin alpha 5
Tested Reactivity Hu
Tested Application FuncSt, ICC/IF, WB
Host Mouse
Clonality Monoclonal
Clone SNAKA51
Isotype IgG2a, kappa
Target Name CD49e / Integrin alpha 5
Antigen Species Human
Immunogen Whole cells corresponding to Human CD49e.
Conjugation Un-conjugated
Alternate Names CD49e; CD49 antigen-like family member E; Integrin alpha-F; Fibronectin receptor subunit alpha; CD antigen CD49e; VLA-5; FNRA; VLA5A; Integrin alpha-5

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note ICC/IF: A representative lot of this antibody detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF).
Activity Assay: A representative lot of this antibody converts alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding. 
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HeLa cells.


Form Liquid
Purification Purification with Protein A.
Buffer PBS and 0.02% Sodium azide.
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 3678 Human ITGA5

Swiss-port # P08648 Human Integrin alpha-5

Gene Symbol ITGA5
Gene Full Name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Background The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]
Calculated MW 115 kDa
PTM Proteolytic cleavage by PCSK5 mediates activation of the precursor. [UniProt]