anti-CD49f / Integrin alpha 6 antibody [4F10] (PE)

anti-CD49f / Integrin alpha 6 antibody [4F10] (PE) for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human


Product Description PE-conjugated Mouse Monoclonal antibody [4F10] recognizes CD49f / Integrin alpha 6
Tested Reactivity Hu
Tested Application FACS, IHC-Fr, IHC-P
Specificity Human CD49f
Host Mouse
Clonality Monoclonal
Clone 4F10
Isotype IgG2b, kappa
Target Name CD49f / Integrin alpha 6
Antigen Species Human
Immunogen SW1222 Human colorectal cell line
Conjugation PE
Alternate Names CD49 antigen-like family member F; ITGA6B; Alpha6p; VLA-6; CD antigen CD49f; CD49f; Integrin alpha-6

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer PBS, 0.1% Sodium azide and Sucrose.
Preservative 0.1% Sodium azide
Stabilizer Sucrose
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 3655 Human ITGA6

Swiss-port # P23229 Human Integrin alpha-6

Gene Symbol ITGA6
Gene Full Name integrin, alpha 6
Background The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. [UniProt]
Calculated MW 127 kDa
PTM Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
Palmitoylation by DHHC3 enhances stability and cell surface expression.