ARG40900

anti-CD51 / Integrin alpha V antibody

anti-CD51 / Integrin alpha V antibody for Western blot,Flow cytometry and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes CD51 / Integrin alpha V
Tested Reactivity Hu, Ms, Rat
Tested Application FACS, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD51 / Integrin alpha V
Antigen Species Human
Immunogen Synthetic peptide derived from Human Integrin alpha V.
Conjugation Un-conjugated
Full Name integrin, alpha V
Alternate Names CD51; VNRA; CD antigen CD51; VTNR; Vitronectin receptor subunit alpha; Integrin alpha-V; MSK8

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:20
WB1:1000 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control A549

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 16410 Mouse ITGAV

GeneID: 3685 Human ITGAV

Swiss-port # P06756 Human Integrin alpha-V

Swiss-port # P43406 Mouse Integrin alpha-V

Gene Symbol ITGAV
Gene Full Name integrin, alpha V
Background This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
Function The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. [UniProt]
Calculated MW 116 kDa

Images (1) Click the Picture to Zoom In

  • ARG40900 anti-CD51 / Integrin alpha V antibody WB image

    Western blot: A549 cell lysate stained with ARG40900 anti-CD51 / Integrin alpha V antibody.