anti-CD71 / Transferrin Receptor antibody [RI7217] (Biotin)
anti-CD71 / Transferrin Receptor antibody [RI7217] (Biotin) for Blocking,Flow cytometry,ICC/IF,Western blot and Mouse
|Product Description||Biotin-conjugated Rat Monoclonal antibody [RI7217] recognizes CD71 / Transferrin Receptor|
|Tested Application||BL, FACS, ICC/IF, WB|
|Specificity||Mouse CD71. The clone RI7217 inhibits cell proliferation in vitro.|
|Target Name||CD71 / Transferrin Receptor|
|Immunogen||DMSO induced Friend erythroleukemia 745.6|
|Alternate Names||TFR1; CD antigen CD71; CD71; T9; p90; TR; Trfr; Transferrin receptor protein 1; TRFR; sTfR; TfR1; TfR; TFR|
|Application Note||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|Buffer||PBS and 0.1% Sodium azide.|
|Preservative||0.1% Sodium azide|
|Storage Instruction||Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||transferrin receptor|
|Background||This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]|
|Function||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [UniProt]|
|Calculated MW||85 kDa|
|PTM||N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
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