anti-CD71 / Transferrin Receptor (soluble) antibody [13E4]
anti-CD71 / Transferrin Receptor (soluble) antibody [13E4] for ELISA,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody
|Product Description||Mouse Monoclonal antibody [13E4] recognizes CD71 / Transferrin Receptor (soluble)|
|Tested Application||ELISA, WB|
|Specificity||Human soluble transferrin receptor and complex between soluble transferrin receptor and transferrin|
|Target Name||CD71 / Transferrin Receptor (soluble)|
|Immunogen||Balb/c mice immunized with purified human soluble transferrin receptor.|
|Full Name||transferrin receptor|
|Alternate Names||TFR1; CD antigen CD71; CD71; T9; p90; TR; Trfr; Transferrin receptor protein 1; TRFR; sTfR; TfR1; TfR; TFR|
|Application Note||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|Purification||Protein A affinity purified.|
|Buffer||PBS (pH.2)) and 0.1 % Sodium azide|
|Preservative||0.1 % Sodium azide|
|Storage instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||transferrin receptor|
|Function||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [UniProt]|
|Research Area||Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody|
|PTM||N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.