anti-CD74 antibody [LN2] (PE)

anti-CD74 antibody [LN2] (PE) for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections,Western blot and Human


Product Description PE-conjugated Mouse Monoclonal antibody [LN2] recognizes CD74
Tested Reactivity Hu
Tested Application FACS, ICC/IF, IHC-Fr, IHC-P, WB
Specificity Human CD74
Host Mouse
Clonality Monoclonal
Clone LN2
Isotype IgG1, kappa
Target Name CD74
Antigen Species Human
Immunogen Cell line SU-DHL-4 nuclei
Conjugation PE
Alternate Names DHLAG; Ii; CD antigen CD74; II; HLA-DR antigens-associated invariant chain; Ia-GAMMA; Ia antigen-associated invariant chain; HLA class II histocompatibility antigen gamma chain; p33; HLADG

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Buffer PBS, 0.1% Sodium azide and Sucrose.
Preservative 0.1% Sodium azide
Stabilizer Sucrose
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 972 Human CD74

Swiss-port # P04233 Human HLA class II histocompatibility antigen gamma chain

Gene Symbol CD74
Gene Full Name CD74 molecule, major histocompatibility complex, class II invariant chain
Background The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [UniProt]
Calculated MW 34 kDa
PTM N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.