ARG21404

anti-CD79b antibody [CB3-1] (APC)

anti-CD79b antibody [CB3-1] (APC) for Flow cytometry,Western blot and Human

Overview

Product Description APC-conjugated Mouse Monoclonal antibody [CB3-1] recognizes CD79b
Tested Reactivity Hu
Tested Application FACS, WB
Specificity Human CD79b. The clone CB3-1 reacts with the β chain of CD79.
Host Mouse
Clonality Monoclonal
Clone CB3-1
Isotype IgG1, kappa
Target Name CD79b
Antigen Species Human
Immunogen Ramos B cells
Conjugation APC
Full Name CD79b molecule, immunoglobulin-associated beta
Alternate Names B29; B-cell-specific glycoprotein B29; Ig-beta; B-cell antigen receptor complex-associated protein beta chain; Immunoglobulin-associated B29 protein; AGM6; IGB; CD antigen CD79b

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl/10^6 cells
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 26 kDa

Properties

Form Liquid
Buffer PBS, Sodium azide and a stabilizing agent
Preservative Sodium azide
Storage instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 974 Human CD79B

Swiss-port # P40259 Human B-cell antigen receptor complex-associated protein beta chain

Gene Symbol CD79B
Gene Full Name CD79b molecule, immunoglobulin-associated beta
Background The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Function Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt]
PTM Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Images (1) Click the Picture to Zoom In

  • ARG21404 anti-CD79b antibody [CB3-1] (APC) FACS image

    Flow Cytometry: Human peripheral blood lymphocytes stained with ARG21404 anti-CD79b antibody [CB3-1] (APC) and ARG21258 anti-CD19 antibody [SJ25-C1] (FITC).