ARG21400

anti-CD79b antibody [CB3-1]

anti-CD79b antibody [CB3-1] for Flow cytometry,Immunoprecipitation,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [CB3-1] recognizes CD79b
Tested Reactivity Hu
Tested Application FACS, IP, WB
Specificity Human CD79b. The clone CB3-1 reacts with the β chain of CD79.
Host Mouse
Clonality Monoclonal
Clone CB3-1
Isotype IgG1, kappa
Target Name CD79b
Antigen Species Human
Immunogen Ramos B cells
Conjugation Un-conjugated
Full Name CD79b molecule, immunoglobulin-associated beta
Alternate Names B29; B-cell-specific glycoprotein B29; Ig-beta; B-cell antigen receptor complex-associated protein beta chain; Immunoglobulin-associated B29 protein; AGM6; IGB; CD antigen CD79b

Application Instructions

Application Suggestion
Tested Application Dilution
FACS< 1 µg/10^6 cells
IPAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 26 kDa

Properties

Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 974 Human CD79B

Swiss-port # P40259 Human B-cell antigen receptor complex-associated protein beta chain

Gene Symbol CD79B
Gene Full Name CD79b molecule, immunoglobulin-associated beta
Background The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Function Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt]
PTM Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.