ARG44794
anti-CDC42 Binding Protein Kinase Beta antibody
anti-CDC42 Binding Protein Kinase Beta antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes CDC42 Binding Protein Kinase Beta |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | CDC42 Binding Protein Kinase Beta |
| Antigen Species | Human |
| Epitope | QRDLEHSLQM EAYERRIRRL EQEKLELSRK LQESTQTVQS LHGSSRALSN SNRDKEIKKL NEEIERLKNK IADSNRLERQ LEDTVALRQE REDSTQRLRG LEKQHRVVRQ EKEELHKQLV EASERLKSQA KELKDAHQQR KLALQEFSEL NERMAELRAQ KQKVSRQLRD KEEEMEVATQ KVDAMRQEMR RAEKLRKELE AQLDDAVAEA SKERKLREHS ENFCKQMESE LEALKVKQGG RGAGATLEHQ QEISKIKSEL EKKVLFYEEE LVRREASHVL EVKNVKKEVH DSESHQLALQ KEILMLKDKL EKSKRERHNE MEEAVGTIKD |
| Conjugation | Un-conjugated |
| Alternate Names | CDC42BPB; CDC42 Binding Protein Kinase Beta; KIAA1124; MRCKB; Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta; Myotonic Dystrophy Protein Kinase-Like Beta; Serine/Threonine-Protein Kinase MRCK Beta; DMPK-Like Beta; CDC42BP-Beta; EC 2.7.11.1; MRCK Beta; CDC42-Binding Protein Kinase Beta (DMPK-Like); CDC42 Binding Protein Kinase Beta (DMPK-Like); CDC42-Binding Protein Kinase Beta; EC 2.7.11; CHOCNS |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y5S2 Human Serine/threonine-protein kinase MRCK beta |
|---|---|
| Gene Symbol | CDC42BPB |
| Gene Full Name | CDC42 Binding Protein Kinase Beta |
| Background | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008] |
| Function | In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. [Uniprot] |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane. [Uniprot] |
| PTM | Methylation, Phosphoprotein. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG44794 anti-CDC42 Binding Protein Kinase Beta antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG44794 anti-CDC42 Binding Protein Kinase Beta antibody at 2.5 µg/mL dilution.
