ARG46377
anti-CENTG1 / PIKE antibody
anti-CENTG1 / PIKE antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CENTG1 / PIKE |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CENTG1 / PIKE |
| Antigen Species | Human |
| Immunogen | A 15 amino acid synthetic peptide within the last 50 amino acids of human CENTG1 / PIKE. |
| Conjugation | Un-conjugated |
| Alternate Names | AGAP2; PIKE; GGAP2; AGAP-2; Cnt-g1; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; Phosphatidylinositol 3-kinase enhancer; Centaurin-gamma-1; GTP-binding and GTPase-activating protein 2; CENTG1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Ion exchange chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q3UHD9 Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 Swiss-port # Q99490 Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 |
|---|---|
| Gene Symbol | AGAP2 |
| Gene Full Name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Background | The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| Calculated MW | 125 kDa |
| PTM | Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. |
Images (2) Click the Picture to Zoom In
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ARG46377 anti-CENTG1 / PIKE antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG46377 anti-CENTG1 / PIKE antibody.
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ARG46377 anti-CENTG1 / PIKE antibody WB image
Western blot: Mouse brain stained with ARG46377 anti-CENTG1 / PIKE antibody.
