Overview

Product Description	Rabbit Polyclonal antibody recognizes CISD2
Tested Reactivity	Hu, Ms, Rat
Tested Application	IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	CISD2
Antigen Species	Human
Immunogen	Recombinant protein of Human CISD2.
Conjugation	Un-conjugated
Alternate Names	MitoNEET-related 1 protein; Miner1; ERIS; Endoplasmic reticulum intermembrane small protein; CDGSH iron-sulfur domain-containing protein 2; Nutrient-deprivation autophagy factor-1; WFS2; NAF-1; ZCD2

Application Instructions

Application Suggestion	Tested Application Dilution IHC-P 1:50 - 1:200 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	A549

Properties

Form	Liquid
Purification	Affinity purification with immunogen.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 493856 Human CISD2 GeneID: 67006 Mouse CISD2 Swiss-port # Q8N5K1 Human CDGSH iron-sulfur domain-containing protein 2 Swiss-port # Q9CQB5 Mouse CDGSH iron-sulfur domain-containing protein 2
Gene Symbol	CISD2
Gene Full Name	CDGSH iron sulfur domain 2
Background	The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Function	Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. [UniProt]
Calculated MW	15 kDa

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