ARG46980
anti-COQ7 antibody
anti-COQ7 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes COQ7 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | COQ7 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human COQ7. |
| Conjugation | Un-conjugated |
| Alternate Names | COQ7; NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase; mitochondrial; 3-demethoxyubiquinone 3-hydroxylase (NADH); Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q99807 Human 5-demethoxyubiquinone hydroxylase, mitochondrial |
|---|---|
| Gene Symbol | COQ7 |
| Gene Full Name | NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial |
| Background | The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] |
| Function | Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (Probable). Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. [UniProt] |
| Cellular Localization | Mitochondrion inner membrane; Membrane; Nucleus; Chromosome. [UniProt] |
| Calculated MW | 24 kDa |
