anti-COX2 antibody

anti-COX2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Inflammation Study antibody
publication_link Publication1


Product Description Rabbit Polyclonal antibody recognizes COX2
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Specificity This antibody detects endogenous levels of Cox2 protein.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name COX2
Antigen Species Human
Immunogen Synthetic peptide around the C-terminus of Human Cox2.
Conjugation Un-conjugated
Alternate Names PHS II; Prostaglandin H2 synthase 2; PHS-2; Cyclooxygenase-2; PGHS-2; COX2; PGG/HS; COX-2; GRIPGHS; hCox-2; PGH synthase 2; Prostaglandin G/H synthase 2; Prostaglandin-endoperoxide synthase 2; EC

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Affinity purification with immunogen.
Purity > 95% (by SDS-PAGE).
Buffer PBS (pH 7.2) and 0.05% Sodium azide.
Preservative 0.05% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 19225 Mouse PTGS2

GeneID: 29527 Rat PTGS2

GeneID: 5743 Human PTGS2

Gene Symbol PTGS2
Gene Full Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Background COX2: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Function COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, that regulates phagocytic microglia. [UniProt]
Highlight Related products:
COX2 antibodies; COX2 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
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Exploring Antiviral Immune Response
Research Area Inflammation Study antibody
Calculated MW 69 kDa
PTM S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.

Images (2) Click the Picture to Zoom In

  • ARG56421 anti-COX2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG56421 anti-COX2 antibody at 1:100 dilution.

  • ARG56421 anti-COX2 antibody WB image

    Western blot: 1) HeLa whole cell lysate, 2) Jurkat whole cell lysate, 3) Raw264.7 whole cell lysate, and 4) Rat lung lysate stained with ARG56421 anti-COX2 antibody at 1:500 dilution.

Specific References

Antagonistic Activities of Lactobacillus rhamnosus JB3 Against Helicobacter pylori Infection Through Lipid Raft Formation

WB / Human

Anh Duy Do et al.
Front Immunol,  (2022)