ARG54363

anti-CX3CR1 (extracellular loop) antibody

anti-CX3CR1 (extracellular loop) antibody for Western blot and Human

Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes CX3CR1 (extracellular loop)
Tested Reactivity Hu
Tested Application WB
Specificity This antibody recognizes human, mouse and rat CX3CR1 (50 kD).
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CX3CR1 (extracellular loop)
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 175-189 of Human CX3CR1.
Conjugation Un-conjugated
Alternate Names CMK-BRL1; GPR13; CX3CR1; CMK-BRL-1; C-X3-C CKR-1; CX3C chemokine receptor 1; V28; CCRL1; GPRV28; CMKBRL1; G-protein coupled receptor 13; CMKDR1; Beta chemokine receptor-like 1; Fractalkine receptor

Application Instructions

Application Note Western blot: use at 1:500 dilution.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control THP-1

Properties

Form Liquid
Purification Immunoaffinity chroma-tography
Buffer PBS (pH 7.4) and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1524 Human CX3CR1

Swiss-port # P49238 Human CX3C chemokine receptor 1

Gene Symbol CX3CR1
Gene Full Name chemokine (C-X3-C motif) receptor 1
Background CX 3 CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, murine, and rat CX 3 CR1 have been cloned and designated V28 and CMKBRL1, CX 3 CR1, and RBS11, respectively. This transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and was renamed CX 3 CR1. Recently, CX 3 CR1was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by factalkine. CX 3 CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines.
Function Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. [UniProt]
Research Area Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody
Calculated MW 40 kDa
PTM This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.