Overview

Product Description	Goat Polyclonal antibody recognizes CXCR4
Tested Reactivity	Hu
Tested Application	WB
Host	Goat
Clonality	Polyclonal
Isotype	IgG
Target Name	CXCR4
Antigen Species	Human
Immunogen	Recombinant peptide derived from within residues 310 aa to the C-terminus of human NPY3R produced in E. coli.
Conjugation	Un-conjugated
Alternate Names	SDF-1 Receptor; CD184 Antigen; LESTR; LAP-3; Fusin; NPYRL; HM89; FB22; C-X-C Chemokine Receptor Type 4; LCR1; D2S201E; Seven-Transmembrane-Segment Receptor, Spleen; NPYY3R; Chemokine (C-X-C Motif), Receptor 4 (Fusin); HSY3RR; Seven Transmembrane Helix Receptor; NPY3R; Neuropeptide Y Receptor Y3; CD184; Neuropeptide Y3 Receptor; NPYR; Chemokine Receptor 4; Leukocyte-Derived Seven Transmembrane Domain Receptor; WHIMS1; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; CXC-R4; Chemokine (C-X-C Motif) Receptor 4; WHIMS; LPS-Associated Protein 3; WHIM

Application Instructions

Application Suggestion	Tested Application Dilution WB
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Epitope affinity purified
Buffer	PBS, 20% Glycerol and 0.05% Sodium Azide
Preservative	0.05% Sodium Azide
Stabilizer	20% Glycerol
Concentration	3 mg/ml
Storage Instruction	For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 7852 Human CXCR4 Swiss-port # P61073 Human C-X-C chemokine receptor type 4
Gene Symbol	CXCR4
Gene Full Name	C-X-C chemokine receptor
Background	This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via G proteins, modulating the activity of downstream effectors such as adenylate cyclase. Coupled to G(i) proteins, mediating inhibition of adenylate cyclase. Involved in the AKT signaling cascade and the regulation of cell migration. Also acts as a receptor for extracellular ubiquitin and binds bacterial lipopolysaccharide (LPS), mediating LPS-induced inflammatory responses. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates. [UniProt]
Cellular Localization	Cell membrane; Cytoplasmic vesicle; Early endosome; Late endosome; Lysosome. [UniProt]
Calculated MW	39.7 kDa
PTM	Disulfide bond; Glycoprotein; Phosphoprotein; Sulfation; Ubl conjugation. [UniProt]

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