ARG46068
anti-Calcium Sensing Receptor antibody
anti-Calcium Sensing Receptor antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Calcium Sensing Receptor |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Calcium Sensing Receptor |
| Antigen Species | Human |
| Immunogen | A 15 amino acid synthetic peptide within the first 50 amino acids of human Calcium Sensing Receptor. |
| Conjugation | Un-conjugated |
| Alternate Names | CASR; Extracellular calcium-sensing receptor; EIG8; FHH; PCaR1; CAR; HHC1; GPRC2A; Parathyroid cell calcium-sensing receptor 1; HHC; PCAR1; CaSR; HYPOC1; FIH; NSHPT |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 115,125 kDa |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CASR |
| Gene Full Name | calcium-sensing receptor |
| Background | The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). |
| Cellular Localization | Cytoplasm, Membrane |
| Calculated MW | 101,120 kDa |
| PTM | N-glycosylated. Ubiquitinated by RNF19A; which induces proteasomal degradation. |
Images (2) Click the Picture to Zoom In
-
ARG46068 anti-Calcium Sensing Receptor antibody IHC-P image
Immunohistochemistry: Human kidney stained with ARG46068 anti-Calcium Sensing Receptor antibody.
-
ARG46068 anti-Calcium Sensing Receptor antibody WB image
Western blot: EL4 stained with ARG46068 anti-Calcium Sensing Receptor antibody.
