ARG40174
anti-Cathepsin S antibody
anti-Cathepsin S antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Publication3
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Cathepsin S |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Cathepsin S |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human Cathepsin S. |
| Conjugation | Un-conjugated |
| Alternate Names | Cathepsin S; EC 3.4.22.27 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | U-87MG | ||||||
| Observed Size | 25 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CTSS |
| Gene Full Name | cathepsin S |
| Background | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. [UniProt] |
| Cellular Localization | Lysosome. [UniProt] |
| Calculated MW | 37 kDa |
Images (2) Click the Picture to Zoom In
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ARG40174 anti-Cathepsin S antibody WB image
Western blot: Human monocytes stained with ARG10664 anti-Cathepsin B antibody and ARG40174 anti-Cathepsin S antibody.
From Ji YF et al. J Alzheimers Dis. (2024), doi: 10.1177/13872877241295361, Fig. 5. A.
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ARG40174 anti-Cathepsin S antibody WB image
Western blot: U-87MG cell lysate stained with ARG40174 anti-Cathepsin S antibody.
Specific References
Interleukin-4 promotes the clearance of amyloid-β by monocyte through enhancing the recognition and intracellular processing of amyloid-β
WB / Human
Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease
WB / Human
Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer's disease.
WB / Human
