anti-Cytokeratin 14 antibody [SQab18101]

anti-Cytokeratin 14 antibody [SQab18101] for IHC-Formalin-fixed paraffin-embedded sections and Human


Product Description Recombinant Rabbit Monoclonal antibody [SQab18101] recognizes Cytokeratin 14
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone SQab18101
Isotype IgG
Target Name Cytokeratin 14
Antigen Species Human
Immunogen Synthetic peptide within aa. 372-472 of Human Cytokeratin 14.
Conjugation Un-conjugated
Alternate Names K14; CK-14; Cytokeratin-14; Keratin, type I cytoskeletal 14; EBS3; EBS4; NFJ; Keratin-14; CK14

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT for 30 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Purification with Protein A.
Buffer PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
Preservative 0.01% Sodium azide
Stabilizer 40% Glycerol and 0.05% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 3861 Human KRT14

Swiss-port # P02533 Human Keratin, type I cytoskeletal 14

Gene Symbol KRT14
Gene Full Name keratin 14, type I
Background This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Function The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. [UniProt]
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Calculated MW 52 kDa
PTM A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.

Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG66351 anti-Cytokeratin 14 antibody [SQab18101] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded esophagus tissue stained with ARG66351 anti-Cytokeratin 14 antibody [SQab18101]. Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0).