ARG10564

anti-Cytokeratin 16 antibody [R20-S]

anti-Cytokeratin 16 antibody [R20-S] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [R20-S] recognizes Cytokeratin 16
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone R20-S
Isotype IgG
Target Name Cytokeratin 16
Antigen Species Human
Immunogen Synthetic peptide around the C-terminus of Human cytokeratin 16
Conjugation Un-conjugated
Full Name keratin 16, type I
Alternate Names KRT16A; K16; FNEPPK; Cytokeratin-16; PC1; K1CP; Keratin-16; CK-16; CK16; NEPPK; Keratin, type I cytoskeletal 16

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3868 Human KRT16

Swiss-port # P08779 Human Keratin, type I cytoskeletal 16

Gene Symbol KRT16
Gene Full Name keratin 16, type I
Background The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Function Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG10564 anti-Cytokeratin 16 antibody [R20-S] IHC-P image

    Immunohistochemistry: Formalin fixed, paraffin embedded luminal cells of the sweat glands of the Human skin (4 µm section) stained with ARG10564 anti-Cytokeratin 16 antibody [R20-S].