anti-Cytokeratin (pan) antibody [C-11] (FITC)
anti-Cytokeratin (pan) antibody [C-11] (FITC) for Flow cytometry and Human,Mouse,Rat,Mammal
Controls and Markers antibody; Signaling Transduction antibody
|Product Description||FITC-conjugated Mouse Monoclonal antibody [C-11] recognizes Cytokeratin (pan)|
|Tested Reactivity||Hu, Ms, Rat, Mamm|
|Specificity||The clone C-11 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.|
|Target Name||Cytokeratin (pan)|
|Immunogen||Keratin-enriched preparation from human epidermoid carcinoma cell line A431.|
|Alternate Names||Keratin, type I cytoskeletal 18; Cytokeratin-18; K18; CK-18; Cell proliferation-inducing gene 46 protein; Keratin-18; CYK18|
|Application Note||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|Purification Note||The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.|
|Buffer||PBS (pH 7.4) and 15 mM Sodium azide|
|Preservative||15 mM Sodium azide|
|Storage Instruction||Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||keratin 18, type I|
|Background||Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. [UniProt]|
|Research Area||Controls and Markers antibody; Signaling Transduction antibody|
|Calculated MW||48 kDa|
|PTM||Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
Images (1) Click the Picture to Zoom In