ARG46120
anti-DEDD2 antibody
anti-DEDD2 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DEDD2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DEDD2 |
| Antigen Species | Human |
| Immunogen | A 11 amino acid synthetic peptide within the first 50 amino acids of human DEDD2. |
| Conjugation | Un-conjugated |
| Alternate Names | death effector domain containing 2; DEDD2; FLAME-3; FLAME3; PSEC0004; DED-containing protein FLAME-3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -170°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8QZV0 Mouse DNA-binding death effector domain-containing protein 2 Swiss-port # Q8WXF8 Human DNA-binding death effector domain-containing protein 2 |
|---|---|
| Gene Symbol | DEDD2 |
| Gene Full Name | death effector domain containing 2 |
| Background | This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| Function | May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 36 kDa |
