ARG41648

anti-DSG1 / Desmoglein 1 antibody

anti-DSG1 / Desmoglein 1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes DSG1 / Desmoglein 1
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name DSG1 / Desmoglein 1
Antigen Species Human
Immunogen Synthetic peptide of Human DSG1 / Desmoglein 1.
Conjugation Un-conjugated
Full Name desmoglein 1
Alternate Names PPKS1; Desmoglein-1; SPPK1; DGI; EPKHIA; CDHF4; DG1; Desmosomal glycoprotein 1; DSG; Cadherin family member 4; Pemphigus foliaceus antigen; EPKHE

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human skin
Observed Size ~ 150 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 1828 Human DSG1

Swiss-port # Q02413 Human Desmoglein-1

Gene Symbol DSG1
Gene Full Name desmoglein 1
Background This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. [UniProt]
Calculated MW 114 kDa

Images (2) Click the Picture to Zoom In

  • ARG41648 anti-DSG1 / Desmoglein 1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human cervix cancer tissue stained with ARG41648 anti-DSG1 / Desmoglein 1 antibody.

  • ARG41648 anti-DSG1 / Desmoglein 1 antibody WB image

    Western blot: Human skin lysate stained with ARG41648 anti-DSG1 / Desmoglein 1 antibody.