ARG65023

anti-DSG1 / Desmoglein 1 antibody

anti-DSG1 / Desmoglein 1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

Signaling Transduction antibody

Overview

Product Description Goat Polyclonal antibody recognizes DSG1 / Desmoglein 1
Tested Reactivity Hu
Tested Application IHC-P
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name DSG1 / Desmoglein 1
Antigen Species Human
Immunogen C-YTTSDTLKPSVHVHD
Conjugation Un-conjugated
Alternate Names PPKS1; Desmoglein-1; SPPK1; DGI; EPKHIA; CDHF4; DG1; Desmosomal glycoprotein 1; DSG; Cadherin family member 4; Pemphigus foliaceus antigen; EPKHE

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P4 - 6 µg/ml
Application Note IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 1828 Human DSG1

Swiss-port # Q02413 Human Desmoglein-1

Background Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008]
Research Area Signaling Transduction antibody
Calculated MW 114 kDa

Images (1) Click the Picture to Zoom In

  • ARG65023 anti-DSG1 / Desmoglein 1 antibody IHC-P image

    Immunohistochemistry: Paraffin embedded Human Skin. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG65023 anti-DSG1 / Desmoglein 1 antibody at 3.8 µg/ml dilution followed by AP-staining.