ARG67345
anti-Dab1 antibody
anti-Dab1 antibody for ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Dab1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Dab1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to a.a. 199-248 of human Dab1. |
| Conjugation | Un-conjugated |
| Alternate Names | DAB1; Dab, Reelin Signal Transducer, Homolog 1 (Drosophila); Name: DAB Adaptor Protein 1; Dab, Reelin Signal Transducer, Homolog 1; Dab Reelin Signal Transducer 1; Disabled Homolog 1 (Drosophila); DAB1, Reelin Adaptor Protein; Disabled (Drosophila) Homolog 1; Disabled Homolog 1; Spinocerebellar Ataxia 37; Yotari; SCA37 |
Application Instructions
| Application Suggestion |
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Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Preservative | 0.02% Sodium Azide |
| Stabilizer | 50% glycerol, 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DAB1 |
| Gene Full Name | DAB Adaptor Protein 1 |
| Background | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017] |
| Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 64 kDa |
| PTM | Phosphoprotein; Ubl conjugation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG67345 anti-Dab1 antibody ICC/IF image
Immunofluorescence: MCF7 stained with ARG67345 anti-Dab1 antibody.
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ARG67345 anti-Dab1 antibody WB image
Western blot: HepG2 stained with ARG67345 anti-Dab1 antibody.
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ARG67345 anti-Dab1 antibody WB image
Western blot: Rat muscle stained with ARG67345 anti-Dab1 antibody.
