ARG54352

anti-DcR3 antibody

anti-DcR3 antibody for Western blot,Immunohistochemistry and Human

Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes DcR3
Tested Reactivity Hu
Tested Application IHC, WB
Specificity This antibody recognizes human, mouse, and rat DcR3 (33kDa).
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name DcR3
Antigen Species Human
Immunogen Peptide corresponding to aa 31-46 of human DcR3 precursor (accession no.
Conjugation Un-conjugated
Alternate Names M68E; Tumor necrosis factor receptor superfamily member 6B; M68; DCR3; Decoy receptor 3; DJ583P15.1.1; Decoy receptor for Fas ligand; DcR3; TR6

Application Instructions

Application Suggestion
Tested Application Dilution
IHCAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human heart, brain and kidney

Properties

Form Liquid
Purification Immunoaffinity chroma-tography
Buffer PBS (pH 7.4) and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 8771 Human TNFRSF6B

Swiss-port # O95407 Human Tumor necrosis factor receptor superfamily member 6B

Gene Symbol TNFRSF6B
Gene Full Name tumor necrosis factor receptor superfamily, member 6b, decoy
Background Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane-associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues.
Function Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Calculated MW 33 kDa

Images (2) Click the Picture to Zoom In

  • ARG54352 anti-DcR3 antibody WB image

    Western Blot: H: human heart; B: brain; K: kidney stained with ARG54352 anti-DcR3 antibody at 1 μg/ml dilution.

  • ARG54352 anti-DcR3 antibody IHC image

    Immunohistochemistry: human heart tissue stained with ARG54352 anti-DcR3 antibody at 1 μg/ml dilution.